氟苯尼考琥珀酸酯合成工藝的優(yōu)化及其藥理學研究.pdf

1、studiesonthesynthesisProcessoPtimizationandPharmaeologieofflorfenieolsuccinateCandidate:QinGuangchengAdvisor:Asso.Pr0LLiZhuboMajor:ElementaryVeterinaryMedicineSPeeialty:VeterinaryPharmacologyandTOxicologySouthwestChongqi

2、ng，University，P.R.ChinaMay，2009西南大學碩士學位論文旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦旦魚旦旦魚旦旦魚旦旦魚旦旦坦3.3.6正交設計優(yōu)化實驗條件結果.................................................................……333.3.7

3、最佳優(yōu)化工藝的穩(wěn)定性考察結果...............……，...................................……333.4討論...............................................................................................................……343.4.1結構驗證............……、.....

4、.........................................................................……343.4.2合成工藝的優(yōu)化.....................................................................................……343.4.3傳統(tǒng)合成工藝與優(yōu)化后工藝的對比分析....................

5、....……，............……343.5本章小結..........................……，.......................................................................……35第四章工業(yè)化合成氟苯尼考琉拍酸酷的方法探討..........................................……，二374.1實驗器材與藥品.......

6、................................................................……，..............……374.2實驗方法........................................................……，.........................................……374.2.1工藝描述...............

7、..................................................................................……374.2.2工藝流程.........……，..……，.....……，，...........................................................……374.2.3合成放大實驗.........................

8、...............................................................……384.3實驗結果與分析討論.，...........................................................................……，……384.3.1合成放大實驗結果............................................

9、.....................................……384.3.2優(yōu)化前后分離純化方法對比研究.........................................................……404.3.3優(yōu)化工藝后合成產品的質量指標.........................................................……414.3.4成本初步評估二，......

10、................................................................................……414.4本章小結..............................................................................……，二，.……，.......……41第五章氟苯尼考墟拍酸鈉在大鼠體內的藥代動力學研究.......

11、.....……，…，..…，…，…，二435.1實驗材料.....................................................................................................……435.1.1實驗動物..............................................................................

12、...................……435.2實驗方法........................................................……，........……，，二，.…，二，.............……435.2.1HPLC方法的建立..................……、...........……，........................................……435.

13、2.2大鼠體內氟苯尼考唬拍酸鈉、氟苯尼考以及氟苯尼考胺消除規(guī)律的研究.............................................................................................................……，........……465.2.3數據處理與分析，…，..…，...........................................

14、...............................……465.3結果與分析....................................................................................................……465.3.IHPLC方法的建立...........................................................

15、..........................……465.3.3氟苯尼考唬拍酸鈉單次肌注在大鼠體組織的分布規(guī)律....................……595.4討論................................................................................................................……625.4.1HPLC檢測方法....

16、................................................................................……，二625.4.2氟苯尼考唬拍酸鈉及衍生物在大鼠體內的動力學特征....................……625.4.3氟苯尼考唬拍酸鈉及衍生物在大鼠體內的組織分布規(guī)律................……635.4本章小結..........................

17、..............................................................................……64第六章氟苯尼考墟拍酸鈉的藥理與毒理學評價...............................................……656.1體內抑菌效果的初步評價...……，...............................................

18、...................……656.1.1材料..............................................................……，....................................……656.1.2方法..............................................................................

19、...........................……656.1.3實驗結果...............……，，..…，…，................................................................……676.1.4討論................................................................................